Kerchner Lab in the department of Neurology & Neurological Sciences
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Welcome to the Kerchner Lab

By the time a patient is diagnosed with Alzheimer’s disease, the brain has already been ravaged: Amyloid plaques and neurofibrillary tangles litter the cerebral cortex. Synapses are gone, neurons are dead, and the brain is grossly atrophied. Not surprisingly, many promising new treatments for Alzheimer's disease have failed to show a benefit when they are given to such patients in clinical trials.

The challenge is to diagnose Alzheimer's disease at an earlier stage. Symptoms and scores on memory tests are not good enough, as these represent the current — inadequate — state-of-the-art. Rather, we need objective tools that can detect Alzheimer's disease before the symptoms are readily apparent.

The Kerchner Lab is dedicated to the study of advanced neuroimaging technologies for early detection of Alzheimer's disease. Additional goals of this research include achieving a better basic understanding of the pathophysiology of Alzheimer's disease and related dementias, and correlating fine anatomical and functional details of the brain to behavior and to risk for neurodegenerative illness.

 

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