Neurology &
Neurological Sciences
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Clinical Research

  1. Serum and cellular biomarkers to predicting disease activity in MS and Neuromyelitis optica
  2. Blood and imaging biomarkers to predict disease activity in MS
  3. Cognitive impairment in MS
  4. The Collaborative International Research in Clinical and Longitudinal Experience for Neuromyelitis Optica (NMO) Studies (CIRCLES)

Neuromyelitis Optica (NMO) is an inflammatory demyelinating disorder of the Central Nervous System (CNS) primarily affecting the optic nerve and spinal cord. Individuals suffering from NMO mainly present with vision impairment, weakness and paralysis, and bladder and bowel problems. NMO patients most often have relapses and progressive neurologic disability.

The Collaborative International Research in Clinical and Longitudinal Experience for Neuromyelitis Optica (NMO) Studies (CIRCLES) is a study that aims to create an open-access repository of data and samples from participants with NMO and from control participants.  These materials are intended to be used in research to better understand NMO pathogenesis, clinical course, and impact of therapy.  Results of these studies may identify the etiology and risk factors, biomarkers for disease progression, and treatment outcomes to guide development of novel therapies.  Findings may also facilitate future research and clinical trials to investigate specific hypotheses related to NMO and to improve the lives of individuals suffering from NMO.

This work is funded by the Guthy-Jackson Charitable Foundation for NMO research. We are currently recruiting participants for the CIRCLES study. Participants will answer patient questionnaires and donate blood samples. If you have NMO or a have a family member with NMO and are interested in participating in the CIRCLES study, please contact Dr. May Han at 650-721-5737.

 

 

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