Neurology &
Neurological Sciences

Neurology & Neurological Sciences Clinical Trials


Population-based Studies of the Prevalence and Predisposing Factors of Peripheral Neuropathy
In collaboration with epidemiologists at UC Berkeley, the study investigates the potential environmental or occupational risk factors for peripheral neuropathy.
PI: Yuen So, MD, PhD

A Phase 2 Study of Verubulin with Radiation and Temozolomide for Adults with Newly Diagnosed Glioblastoma  
PI: Lawrence Recht, MD (NCT01285414)

Protocol Number: AGLU09411 A Phase 4, Open-label, prospective study in patients with Pompe disease to evaluate the efficacy and safety of Alglucosidase alfa produced at the 4000 L scale
PI: John Day, MD, PhD (NCT01526785)

Brain Networks in Neurodegenerative Diseases
To prospectively evaluate the application of FDG PET to aid in the diagnosis of Parkinson’s disease and other atypical Parkinsonian syndromes. 
PI: Kathleen Poston, MD, MS

Transient Ischemic Attack (TIA) Triage and Evaluation of Stroke Risk
PI: Gregory Albers, MD, (NCT01423201)

An Exploratory Study to Assess Two Doses of GSK2402968 in the Treatment of Ambulant Boys with Duchenne Muscular Dystrophy
PI: Yuen So, MD, PhD (NCT01462292)

A Phase 2 Study of MEDI-575 (Monoclonal Antibody) in Adult Subjects with Recurrent Glioblastoma Multiforme 
To evaluate the progression-free survival at 6 months in adult subjects treated with MEDI-575. 
PI: Lawrence Recht, MD (NCT01268566)

The Aging Brain: Risk for Dementia
This study will enroll older individuals with or without cognitive problems with the goal of determining which factors are most predictive developing dementia. 
PI: Geoffrey Kerchner, MD, PhD

Microstructural Brain Imaging Using Ultra-High Field 7-Tesla MRI 
This study aims to find the earliest structural changes corresponding to Alzheimer’s disease and other neurodegenerative conditions and to correlate these changes with memory and other behavioral measures. 
PI: Geoffrey Kerchner, MD, PhD

Resting-State Functional MRI for Diagnosing Alzheimer’s Disease
The goal is to develop a resting-state functional connectivity biomarker able to detect signal in MCI and to distinguish AD from non-AD dementia at the single-patient level. 
PI: Michael Greicius, MD, MPH

Phase 3 Study to Evaluate the Efficacy and Safety of Desmoteplase in Subjects with Acute Ischemic Stroke (DIAS-4) 
PI: Maarten Lansberg, MD, PhD (NCT00856661)

Prognosis of Critically Ill Neurological Patients
To determine how well health care providers can predict future neurological outcomes, if they differ in the prediction of outcome, and to assess outcomes of this patient population. 
PI: Anna Finley-Caulfield, MD

Ralozifene for women with Alzheimer’s disease
A multisite pilot randomized trial of raloxifene the treatment of women with Alzheimer’s disease.
PI: Victor Henderson, MD, MS (NCT00368459)

A Phase II Trial of MABT5102A on Brain Amyloid and Related Biomarkers in Patients with Mild to Moderate Alzheimer's Disease (BLAZE)
PI: Geoffrey Kerchner, MD, PhD 

Diagnostic Utility of MRI in Intracerebral Hemorrhage
To measure the impact of state-of-the-art brain imaging technology on the diagnosis and treatment of patients with a spontaneous ICH to improve patient outcome. 
PI: Christine Wijman, MD (NCT00363662

Pharmacodynamic Study of CK-2017357 in Patients with Generalized Myasthenia Gravis on Standard Therapy
PI: Yuen So, MD, PhD (NCT01268280)

Prognostic Value of MRI and Biomarkers in Comatose Post-cardiac Arrest Patients (COMA) 
To assess the value of state-of-the art brain imaging techniques (MRI), and blood tests in predicting outcome in these patients. 
PI: Christine Wijman, MD
Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT) Trial
A phase 3 study to determine if aspirin and clopidogrel together reduces the risk of stroke, heart attacks and other complications compared to aspirin alone. 
PI: Gregory Albers, MD (NCT00991029)

Antihypertensive Treatment of Acute Cerebral Hemorrhage (ATACH )-II
To determine the therapeutic benefit of intensive blood pressure reduction relative to standard treatment in acute intracerebral hemorrhage.
PI: Christine Wijman, MD (NCT01176565)

Stroke Hyperglycemia Insulin Network Effort (SHINE ) Trial
To determine safety and therapeutic benefit of treating hyperglycemic acute ischemic stroke
patients with targeted glucose concentration (80mg/dL - 130 mg/dL).
PIs: James Quinn, MD and Christine Wijman, MD (NCT01369069)

The Parkinson's Genetic Research Study (PaGeR)
PIs: Kathleen Poston, MD, MS and Rosalind Chuang, MD (NCT01558479)

Clot Lysis: Evaluating Accelerated Resolution of Intraventricular Hemorrhage Phase 3 (CLEAR III) 
To determine if EVD placement with low-dose rt-PA improves modified Rankin Scale scores at 6 months compared to subjects treated with EVD placement with placebo. 
PI: Christine Wijman, MD (NCT00784134)

Clinical and Genetic Characterization of Myotonic Dystrophy
PI: John Day, MD, PhD

Safety and Efficacy Evaluation of Threshold Sound Conditioning by Conditioning-enhanced
Hearing Aid
PI: Jaime Lopez, MD

NeuroThera® Efficacy and Safety Trial - 3 (NEST-3) 
To assess the safety and efficacy of transcranial laser therapy (TLT) with the NeuroThera® Laser System for the treatment of acute ischemic stroke within 24 hrs of stroke onset. 
PI: Gregory Albers, MD (NCT01120301)

ACE -Seniors (Activities for Cognitive Enhancement of Seniors)
A randomized trial of healthy older adults to assess effects of innovative activities on
remediation of age-related cognitive decline.
PI: Victor Henderson, MD, MS (NCT01094509)

Insulin Resistance Intervention After Stroke Trial (IRIS)
To determine if pioglitazone will reduce the overall risk for fatal or nonfatal stroke or MI among non-diabetic men and women over age 44 years with insulin resistance and recent ischemic stroke or TIA. 
PI: Maarten Lansberg, MD (NCT00091949)

CRISP : A multi-center cohort study of acute stroke patients who are treated with endovascular therapy
The study is designed to determine optimal CT perfusion criteria to select patients for endovascular stroke treatment.
PI: Maarten Lansberg, MD, PhD

NeuRx Diaphragm Pacing System (DPS) for Humanitarian Use in Amyotrophic Lateral Sclerosis (ALS)
PI: Dr. Yuen So (NCT01605006)

Tissue Banking of Blood, Spinal Fluid or Skin Biopsy for the Research of Neurological Diseases
PI: Dr. Yuen So

Subject Database and Specimen Repository for Neuromuscular and Neurodegenerative Disorders
PI: Dr. John Day

INC 6604-Development and Validation of a Disability Severity Index for Charcot-Marie-Tooth Disease (CMT)
PI: Dr. John Day

Inherited Neuropathies Consortium
PI: Dr. John Day

HDE Post-Approval Study (PAS) of NeuRx DPS™ for ALS
PI: Dr. Yuen So (NCT01605006)

Collaborative International Research in Clinical and Longitudinal Experience for Neuromyelitis Optica (NMO) Studies (CIRCLES)
This is an open-access repository of clinical data and biological samples from patients with Neuromyelitis Optica (NMO) and from control participants. The goal of this longitudinal study is to understand the natural history of NMO and environmental influences to identify novel biomarkers to monitor disease activity and to develop effective therapies.
PI: May Han, MD


Quantifying Collateral Perfusion in Cerebrovascular Disease 
This study utilizes MRI to improve the detection and assessment of collateral blood vessels in patients with diseases of the brain, such as Moyamoya disease and stroke. 
PI:  Greg Zaharchuk, MD, PhD (NCT01419275)



To Evaluate the Efficacy and Safety Of Ocrelizumab in Comparison to Interferon Beta-1a (Rebif) in Patients With Relapsing Multiple Sclerosis
PI: Jeffrey Dunn, MD (NCT01412333)

JCV Antibody Program in Patients with Relapsing Multiple Sclerosis Receiving or Considering Treatment With Tysabri: STRATIFY-2  
PI: Jeffrey Dunn, MD (NCT01070836)

An Extension Protocol for Multiple Sclerosis Patients Who Participated in Previous Studies of Alemtuzumab
PI: Jeffrey Dunn, MD (NCT00930553)

Biobank For MS And Other Demyelinating Diseases
To establish a large, longitudinal collection of high quality samples and data from subjects
with MS, selected other demyelinating diseases as a shared resource to scientists researching
the causes, sub-types, and biomarkers of MS and related demyelinating diseases.
PI: Jeffrey Dunn, MD (NCT00445367)

Ponesimod in Patients With Relapsing-remitting Multiple Sclerosis -Extension Study
To investigate the long term safety, tolerability, and efficacy of ACT-128800 (Ponesimod) in patients with relapsing remitting Multiple Sclerosis
PI: Jeffrey Dunn, MD (NCT01093326)

Large-scale, Multi-disciplinary Sample and Data Repository for Multiple Sclerosis and Related Demyelinating Diseases
PI: Jeffrey Dunn, MD (NCT00445367)


Vitesse Intracranial Stent Study for Ischemic Therapy (VISSIT)
This study is evaluating a new intracranial stent for intracranial stenosis.
PI: Michael P. Marks, MD


A Phase I Study of Rindopepimut After Conventional Radiation in Children With Diffuse Intrinsic Pontine Gliomas
Safety and efficacy analysis of treating pediatric diffuse intrinsic pontine glioma patients with the EGFRvIII peptide vaccine after conventional radiation.
PI: Paul Fisher, MD
Sub-PIs: Albert J Wong, MD, Michael S.B. Edwards, MD, Michelle Monje-Deisseroth, MD, PhD, and Gordon Li, MD (NCT01058850)

Erlotinib Versus Oral Etoposide in Patients with Recurrent or Refractory Pediatric Ependymoma
PIs: Paul Fisher, MD, Sonia Partap, MD, and Neysa Maria Marina (NCT01032070)

Bevacizumab and Lapatinib in Children with Recurrent or Refractory Ependymoma
PI: Sonia Partap MD
Sub-PIs: Paul Graham Fisher, MD, Michelle Monje-Deisseroth, MD, PhD, Cynthia Campen, MD and Yoon-Jae Cho, MD (NCT00883688)

For more details on all of our clinical trials visit the SOM Clinical Trial Database or visit

Last updated 8/16/2012

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