Andreasson Lab in the department of Neurology & Neurological Sciences
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Welcome to the Andreasson Lab

We are interested in understanding the mechanisms by which neuroinflammation elicits synaptic and neuronal injury in chronic and acute models of neurological disease. Our foot in the door has been the study of the cyclooxygenase-2 (COX-2) pathway and its downstream prostaglandin receptor signaling pathways, which function in important ways in modulating the inflammatory response in brain in models of Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), and stroke. Thus this pathway functions across a broad spectrum of neurodegenerative diseases, and may potentially modulate inflammatory responses and neuronal injury via conserved cellular and molecular mechanisms.  We use genetic and pharmacologic strategies as well as in vitro culture approaches to define COX-2/prostaglandin receptor mediated mechanisms of action in eliciting synaptic and neuronal injury in models of human neurological disease.  Our long-term goal is to (1) further understand how neuroinflammatory processes injure synapses and neurons and disrupt circuits,  (2) define the contribution of the COX-2/prostaglandin signaling pathways in this process, and (3) develop therapeutic strategies targeting injurious inflammatory processes in human neurological diseases.

 

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