MARTHA J. MORRELL, M.D.
Clinical Professor of Neurology, Stanford University
Dr. Morrell is a Clinical Professor of Neurology at Stanford University and Chief Medical Officer of NeuroPace, Inc. Prior to July 2004, she was the Caitlin Tynan Doyle Professor of Clinical Neurology at Columbia University and Director of the Columbia Comprehensive Epilepsy Center at New York Presbyterian Hospital in New York City. Previously she was on the faculty of the Stanford University School of Medicine where she served as Director of the Stanford Comprehensive Epilepsy Center. A graduate of Stanford Medical School, she completed residency training in Neurology at University of Pennsylvania, as well as fellowship training in EEG and epilepsy.
Dr. Morrell’s clinical and academic work has been directed entirely to the care of people with epilepsy. She has especially focused on gender differences in epilepsy and effects of epilepsy on reproductive health. At NeuroPace, she directs clinical investigations to investigate the safety and efficacy of an implanted responsive neurostimulator in adults with medically uncontrolled epilepsy.
Dr. Morrell has more than 150 publications on epilepsy and has spoken extensively on epilepsy nationally as well as internationally. She served as a member of the Board of Directors of the American Epilepsy Society, as well as a member and then Chair of the Scientific Program Committee and the Women with Epilepsy Committee and Special Interest Group. She served on the Council of the American Neurological Association. Her service to the Epilepsy Foundation includes as a member of the Board of Directors and Past Chair of the Board, Chair of the Research and of the Public Information and Education Committees, co-Founder of the Women with Epilepsy Initiative, and service on other committees. She is a Fellow of the American Academy of Neurology and past Chair of the Epilepsy Section. She chaired the Epilepsy Therapy Section of the CDC’s Living with Epilepsy Conference. She was Chair of the Commission on Diagnostic Strategies, member of the Scientific Program Committee, and is an elected Ambassador for Epilepsy of the International League Against Epilepsy. Dr Morrell was the recipient of the American Epilepsy Society 2007 Service Award.
Training and Employment
1984-1985: Medical Internship, University of Pennsylvania
1985-1988: Neurology Residency, University of Pennsylvania
1988-1990: Epilepsy and EEG Fellowship, University of Pennsylvania
1990-1994: Assistant Professor Neurology, Stanford University
1994-1998: Associate Professor Neurology, Stanford University
1998-2004: Professor of Clinical Neurology, Columbia University
2004-present: Clinical Professor of Neurology, Stanford University
2004-present: Chief Medical Officer, NeuroPace, Inc.
Selected Peer-Reviewed Publications
- Morrell MJ, Phillips C, O'Connor M, Sperling M. Speech during partial seizures: intracranial EEG correlates. Epilepsia 1991; 32(6):866-899.
- Sperling MR, O'Connor MJ, Morrell MJ, Phillips CA, Bridgman PA, Tatum WO, French JA. A non-invasive protocol for anterior temporal lobectomy. Neurology 1992; 42(2): 416-421.
- Morrell MJ, Sperling MR, Stecker M, Dichter MA. Sexual dysfunction in partial epilepsy: a deficit in physiological sexual arousal. Neurology 1994; 44(2): 243-247.
- Cummings LN, Giudice L, Morrell MJ. Ovulatory function in epilepsy. Epilepsia 1995; 36:355-359.
- Sum J, Morrell MJ. Predictive value of the first scalp-sphenoidal ictal recording in determining localization of the epileptogenic region. Epilepsia 1995; 36(10): 1033-1040.
- Desmond JE, Sum JM, Wagner AD, Demb JB, Shear PK, Illes J, Glover GH, Gabrieli JDE, Morrell MJ. Language lateralization in Wada-tested patients using functional MRI. Brain 1995;118;1411-1419.
- Toczek MT, Morrell MJ, Silverberg GA, Lowe GM. Cerebellar hemorrhage complicating temporal lobectomy. J Neurosurg 1996;85:718-722.
- Morrell MJ, Guldner GT. Self-reported sexual function and sexual arousability in women with epilepsy. Epilepsia 1996; 37:1204-1210.
- Guldner GT, Morrell MJ. Nocturnal penile tumescence and rigidity evaluation in men with epilepsy. Epilepsia 1996; 37:1211-1214.
- Marsh L, Morrell MJ, Shear PK, Sullivan EV, Freeman H, Marie A, Lim KO, Pfefferbaum A. Cortical and hippocampal volume deficits in temporal lobe epilepsy. Epilepsia 1997; 38(5): 576-587.
- Bergey GK, Morris HH, Rosenfeld W, Blume WT, Penovich PE, Morrell MJ, Liederman DB, Crockatt JG, LaMoreaux L, Garofalo E, Pierce M, and the US Gabapentin Study Group 88/89.Gabapentin monotherapy: I. An 8-day, double-blind, dose-controlled, multicenter study in hospitalized patients with refractory complex partial or secondarily generalized seizures. Neurology 1997; 49(3): 739 45.
- Toczek MT, Morrell MJ, Risinger MW, Shuer L. Intracranial ictal recordings in mesial frontal lobe epilepsy. J Clinical Neurophysiol 1997; 14: 499-506.
- Seale C, Morrell MJ, Nelson L, Druzin M. Analysis of the prenatal and gestational care given to women with epilepsy. Neurology 1998; 51:1039-1045.
- McLean MJ, Morrell MJ, Willmore LJ, Privitera MD, Faught RE, Holmes GL, Magnus-Miller L, Podolnick PB, Rose-Legatt A. Safety and tolerability of gabapentin as adjunctive therapy in a large, multicenter study..Epilepsia 1999; 40(7) :965-972.
- Morrell MJ. Dosing to efficacy with Neurontin: the STEPS trial. Epilepsia 1999; 40 (S6): S23-S26.
- Lansberg MG, O’Brien MW, Norbash AM, Moseley ME, Morrell M, Albers GW. MRI abnormalities associated with partial status epilepticus. Neurology 1999 23; 52(5):1021-1027.
- Barry JJ, Morrell MJ, Atzmon O. Use of the hypnotic induction profile and seizure induction to differentiate nonepileptic from epileptic events. Epilepsia 2000;41:81-84.
- Laxer K, Blum D, Abou-Khalil BW, Morrell MJ, Lee D, Data JL, Monoghan E. Assessment of ganaxolone’s anticonvulsant activity using a randomized, double-blind, presurgical trial design. Epilepsia 2000; 41:1187-1194.
- Zipf-Williams EM, Shear PK, Strongin D, Winegarden BJ, Morrell MJ. Qualitative block design performance in epilepsy patients. Arch Clin Neuropsych 2000; 15(2): 149-157.
- Spencer DC, Morrell MJ, Risinger MW. The role of the intracarotid amobarbital procedure in evaluation of patients for epilepsy surgery. Epilepsia 2000; 41:320-325.
- Spencer DC, Hwang J, Morrell MJ. Fenfluramine-phenteramine (Fen-Phen) and seizures: evidence for an association. Epilepsy Beh 2000; 1(6): 448-452.
- Morrell MJ, Sarto GE, Osborne Shafer P, Borda EA, Herzog A, Callanan M. Health issues for women with epilepsy: a descriptive survey to assess knowledge and awareness among healthcare providers. J Women’s Health Gender –Based Med 2000; 9: 959-965.
- Barry JJ, Atzman O, Morrell MJ. Discriminating between epileptic and nonepileptic events: the utility of hypnotic seizure induction. Epilepsia 2000; 41(1): 81-84.
- Morrell MJ, Flynn KL, Seale CG, Done S, Paulson AJ, Flaster ER, Ferin M. Reproductive dysfunction in women with epilepsy: antiepileptic drug effects on sex-steroid hormones. CNS Spectrums 2001 6(9): 771-786.
- Marsh L, Sullivan EV, Morrell M, Lim KO, Pfefferbaum A. Structural brain abnormalities in patients with schizophrenia, epilepsy, and epilepsy with chronic interictal psychosis. Psychiatry Res. 2001 Nov 5; 108(1): 1-15.
- Karceski S, Morrell MJ, Carpenter D. Treatment of epilepsy: Expert Consensus Method. Epilepsy and Behavior 2001; 2 (6 pt 2) A1-A50.
- Morrell MJ, Guidice L, Seale C, Paulson A, Done S, Flaster E, Ferin M, Sauer M. Ovulatory dysfunction in women with epilepsy receiving antiepileptic drug monotherapy: an interaction of syndrome and treatment. Annals Neurol 2002; 52(6): 704-11.
- Morrell MJ, Isojarvi J, Taylor A, Dam M, Ayala R, Gomez G, O’Neill F, Tennis P, Messenheimer J. Higher androgens and weight gain with valproate compared with lamotrigine for epilepsy. Epilepsy Research 2003; 54: 189-199.
- Pack AM, Olarte LS, Morrell MJ, Flaster E, Resor SR, Shane E. Bone mineral density in an outpatient population receiving enzyme-inducing antiepileptic drugs. Epilepsy Behav. 2003; 4 (2): 169-74.
- Ferin M, Morrell M, Xiao E, Kochan L, Qian F, Wright T, Sauer M. Endocrine and metabolic responses to long-term monotherapy with the antiepileptic drug valproate in the normally cycling rhesus monkey. J Clin Endocr Metab 2003; 88(6): 2908-2915.
- Morrell MJ, Leppick I, French JA, Ferrendelli J, Han J, Magnus L. The KEEPER trial: levetiracetam adjunctive treatment of partial onset seizures in an open-label community based study. Epilepsy Research 2003; 54: 153-161.
- Leppik I, Morrell M, Godfroid P, Arrigo C. Seizure-free days observed in randomized placebo-controlled add-on trials with levetiracetam in partial epilepsy. Epilepsia. 2003; 44(10): 1350-2.
- Ferrendelli JA, French J, Leppik I, Morrell MJ, Herbeuval A, Han J. Use of levetiracetam in a population of patients aged 65 years and older: a subset analysis of the KEEPER trial. Epilepsy Behav. 2003;4(6):702-709.
- Pack A, Morrell MJ, Marcus R, Holloway L, Flaster E, Done S, Randall A, Seale C, Shane E. Bone mass and turnover in women with epilepsy on antiepileptic drug monotherapy. Ann Neurol. 2005 Feb;57(2):252-7.
- Morrell MJ, Flynn KL, Flaster E, Doñe S, Kalayjian L, Pack A. Sexual dysfunction, sex steroid hormone abnormalities and depression in women with epilepsy treated with antiepileptic drugs. Epilepsy Behav. 2005 May;6(3):360-5.
- Hirsch LJ, Weintraub D, AB, Du Y, Buchsbaum R, Spencer H, Hager M, Straka T, Bazil CW, Adams DJ, Resor SR Jr., Morrell MJ. Correlating lamotrigine serum concentrations with tolerability in patients with epilepsy. Neurology. 2004 Sep 28;63(6):1022-6.
- Karceski S, Morrell MJ, Carpenter D. Treatment of epilepsy: Expert Consensus Method. Epilepsy Behavior 2005, Treatment of epilepsy in adults: expert opinion, 2005;7 Suppl 1:S1.
- Morrell MJ. Brain stimulation for epilepsy: can scheduled or responsive neurostimulation stop seizures? Curr Opin Neurol. 2006;19(2):164-8.
- Pack AJ, Morrell MJ, Shane E, Pflaster E. Bone health in young women with epilepsy after one year of antiepileptic drug monotherapy. Neurology 2008;70(18):1586-93.
- Morrell MJ, Hayes FJ, Sluss PM, Adams JM, Bhatt M, Ozkara C, Warnock CR, Isojarvi J. Higher incidence of treatment-emergent hyperandrogenism, ovulatory dysfunction and polycystic ovary syndrome with valproate than lamotrigine: Results of a prospective, randomized, 1-year study in young women with epilepsy. Annals of Neurology 2008;64(2):200-11.
- Meador KJ, Baker GA, Browning N, Clayton-Smith J, Combs-Cantrell DT, Cohen M, Kalayjian LA, Kanner A, Liporace JD, Pennell PB, Privitera M, Loring DW; NEAD Study Group (member of NEAD Study Group. Cognitive function at 3 years of age after fetal exposure to antiepileptic drugs.N Engl J Med. 2009 Apr 16;360(16):1597-605.
- Skarpaas TL, Morrell MJ. Intracranial stimulation therapy for epilepsy. Neurotherapeutics. 2009 Apr;6(2):238-43.
- Meador KJ, Penovich P, Baker GA, Pennell PB, Bromfield E, Pack A, Liporace JD, Sam M, Kalayjian LA, Thurman DJ, Moore E, Loring DW; NEAD Study Group (member of NEAD Study Group). Antiepileptic drug use in women of childbearing age. Epilepsy Behav. 2009 Jul;15(3):339-43.

